Stable-Isotope Tracers

[1,2-13C2]-D-glucose and [U-13C6]-D-glucose

Glucose-based tracers are the workhorses of in vivo rodent and primate as well as human studies in all metabolic conditions as well as cancer. These tracers are appropriate to develop biomarker metabolite profiles for drug response, toxicity, diagnostic discovery research or determining glucose tolerance, gluconeogenesis, hepatic glucose production and may replace the clamp type approach. Carboxylase activity can also be readily studied using these tracers.

Other applications include metabolic studies for de novo fatty acid and cholesterol synthesis, complete glucose oxidation and TCA cycle function.

These tracers are relatively inexpensive and is recommended for in vivo or human studies.

[U-13Cn]-fatty-acid

This tracer is the workhorse of in vitro, in vivo rodent/primate as well as human studies in all metabolic conditions related to fatty acid turnover, complete oxidation and carbon exchange among fatty acids. This tracer is appropriate to develop biomarker metabolite profiles for drug response, toxicity, diagnostic discovery research or determining fatty acid disposal via oxidation (ß carbon), cholesterol synthesis, fatty acid absorption, transport from liver and fat tissues. Carboxylase activity can also be readily studied using this tracer.

Other applications include metabolic studies for de novo fatty acid breakdown, complete fatty acid oxidation in peroxisomes or mitochondria.

This tracer is relatively inexpensive and is recommended for in vitro, in vivo or human studies.